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We performed a retrospective study to characterize the type,frequency,and timing of neurologic complications in patients with B-cell chronic lymphocytic leukemia(B-CLL).We reviewed 962 total charts with a median follow-up time of 57.5 months.There were 109 cases(11.3%)of neurologic complications,including 69 cases(7.2%)of herpes zoster infection,17 cases (1.8%)of other opportunistic infection,14 cases(1.5%)of treatment-related conditions,eight cases(0.8%)of direct leukemic involvement of neural tissue,and 1 case(0.1%)of intracranial hemorrhage.No cases of a non-zoster opportunistic injection present in early stage(Rai stage 0-2)B-CLL,and only one case of direct leukemic involvement of neural structures presented in early-stage B-CLL.Of the 25 cases non-zoster or treatment- related complications,only 5 presented before 6 years from the initial B- CLL diagnosis.Three of these were in advanced stage B-CLL,staging could not be determined in one,and one presented in early stage B-CLL.We conclude that the overall neurologic complication rate of B-CLL is low,and that the Rai stage of the disease correlates best with the risk of developing neurologic complications.The occurrence of a related non- zostern neurologic complication in a patient with B-CLL stage 0-2 approaches. |
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herpes zoster
intracerebral hemorrhage
leukemia
leukemia,neurologic findings assoc.with
meningitis
meningitis,leukemic
neoplasm,metastatic to CNS
neoplasm,metastatic to CNS,hemorrhagic
opportunistic infection,CNS
review article
thrombocytopenia
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